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World Thrombosis Day

October 13, 2023 by Paul Leave a Comment

It is World Thrombosis Day today. To show support you should be wearing red and blue. This could be a little awkward the day before the election! These are some important facts about blood clots you might like to share with others ... Over 50% of all blood clots occur either in hospital or soon after discharge. Globally, over 10 million cases of … [Read more...]

Factor V Leiden – Family screening

June 29, 2023 by Paul Leave a Comment

Factor V Leiden is an inherited condition with a risk of thrombosis. Heterozygous If you have one parent with the mutation and you have inherited factor V Leiden from them, your risk of a blood clot is 5 to 7 times higher than normal. Homozygous If both parents have Factor V Leiden and you have inherited two copies of the mutation, your risk of a blood clot is 40 … [Read more...]

Factor V Leiden and the Pill

June 22, 2023 by Paul Leave a Comment

The oral contraceptive was first introduced in the US in 1960. Within two years, over a million women in the US were taking the “pill” as a safe, effective form of contraception. The use snowballed, and hundreds of millions of women now use oral contraceptives. Some regard it as the most socially significant advance in modern medicine as it gave women reproductive … [Read more...]

Blood clot art

June 18, 2023 by Paul Leave a Comment

We are currently in Adelaide for Angela’s birthday. During our visit we thought we should get a little culture, so we visited Adelaide Art Gallery. It has quite a varied collection of art, with some beautiful Australian landscape paintings and unique aboriginal art. However, one display particularly caught Angela’s eye. It is one of the permanent displays, a piece by the … [Read more...]

Factor V Leiden – What does it mean for me?

June 15, 2023 by Paul Leave a Comment

What is my risk of a clot? In the general population, the risk of having a blood clot (either a deep vein thrombosis or pulmonary embolus) is quoted at 1 in 2000 people each year. However, the risk is highly dependent on your age. If you are in your twenties the risk is about 1 in 10,000 and if you are over 70 years it is as high as 1 in 200. If you have the factor V Leiden … [Read more...]

Factor V Leiden – What is factor V Leiden?

June 8, 2023 by Paul Leave a Comment

In the last two posts, I discussed how factor V works and how Protein C controls its activity. In this post, I will look at the difference between Factor V and Factor V Leiden. What is Factor V Leiden? Factor V Leiden is an alternative form of Factor V caused by a small mutation in the factor V gene. First, I will take you through some basic genetics to help you … [Read more...]

How long should I stay on anticoagulants – Coronation Concert Edition

June 1, 2023 by Paul Leave a Comment

How long you need anticoagulants depends on the balance of risks between having a blood clot and bleeding; these will differ for each individual. Your specialist will decide the length of time anticoagulants are needed in your particular case. This is just a guide. To help you remember, I have added song titles from the performers at the Coronation Concert. I have even … [Read more...]

Factor V Leiden – Controlling Factor V

May 25, 2023 by Paul Leave a Comment

I explained how Factor V helped to speed up clotting in my last post. I compared it to pouring petrol on a fire. In this post, I will look at how Factor V is controlled. Clotting is complex but quite precisely controlled. It only takes place when and where you need it. You want the bleeding to stop at the site of the injury when you cut your finger, but you don’t want … [Read more...]

The Royal Disease

May 18, 2023 by Paul Leave a Comment

Since the Coronation, the internet and magazines have been full of pictures of Royalty. So I thought it would be appropriate to post on the "Royal Disease", namely Haemophilia. Although this is not strictly related to taking anticoagulants, it is a serious disorder affecting clotting. Queen Victoria Queen Victoria was a carrier for Haemophilia. She had nine children. Her … [Read more...]

Factor V Leiden – What is Factor V?

May 10, 2023 by Paul Leave a Comment

In my introductory post about Factor V Leiden, I discussed how this is an inherited condition and relatively common affecting around 4% of people of European decent. In this post I will take you through some of the basics of clotting to help you understand why Factor V Leiden increases your risk of clots. Factor V Factor V Leiden is an abnormal form of the clotting … [Read more...]

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About Us

Paul & Angela

Paul, a specialist haematologist says, “I have a passion for improving anticoagulant management and I’m on anticoagulants myself. My wife, Angela, trained as a doctor, but has concentrated instead on raising our large family. We live in beautiful New Zealand and run INR Online, providing warfarin management software for health professionals.” More

Recent posts

  • World Thrombosis Day
  • Factor V Leiden – Family screening
  • Factor V Leiden and the Pill
  • Blood clot art
  • Factor V Leiden – What does it mean for me?

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